The overall HR was 1.40 (95% CI, 1.17–1.68). Breast cancer is the second most common cancer worldwide and the most commonly occurring malignancy in women [1]. If you would like more information about this site please email the administrator (remove This site is not intended as J Breast Cancer. To the best of our knowledge, this is the first dose-response meta-analysis providing comprehensive insights into the association between the time from the last pregnancy to breast cancer diagnosis and the overall mortality of PABC. Compared to nulliparous women, the mortality was almost 60% higher in women with PABC diagnosed at 12 months after the last delivery (HR = 1.59, 95% CI 1.30–1.82), and the mortality was not significantly different at 70 months after the last delivery (HR = 1.14, 95% CI 0.99–1.25). Second, the meta-analysis was based on data from observational studies; although most of the included studies adjusted for several relevant confounders (including age, year of diagnosis, tumour stage, axillary lymph node status, oestrogen receptor, hormonal receptor status, HER2 status, family history, etc. Effect of pregnancy on prognosis for young women with breast cancer. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. Moller H, Purushotham A, Linklater KM, Garmo H, Holmberg L, Lambe M, Yallop D, Devereux S. Recent childbirth is an adverse prognostic factor in breast cancer and melanoma, but not in Hodgkin lymphoma. About.com, Rare Diseases - Trisomy 18 (Edwards syndrome), PubMed Health - Trisomy 18 (Edwards syndrome), Chromosome 18 Registry & Research Society - Trisomy 18, Trisomy 21 Information (Down Syndrome) >>. statement and Cancer Epidemiol Biomark Prev. Cancers coinciding with childbearing: delayed diagnosis during pregnancy? 2016;59(4):779–88. My doctor was back in the office and I finally got to have a conversation with her about my prognosis. Citation: Wu S, Lv Z, Wang Y, Sun L, Jiang Z, Xu C, et al. Petrek JA, Dukoff R, Rogatko A. Prognosis of pregnancy-associated breast cancer. 2018;95:30–7. Madaras L, Kovacs KA, Szasz AM, Kenessey I, Tokes AM, Szekely B, Baranyak Z, Kiss O, Dank M, Kulka J. Clinicopathological features and prognosis of pregnancy associated breast cancer - a matched case control study. Poor Prenatal Diagnosis This website is dedicated to help parents decide in a time of crises how to proceed and where to turn for help and resources. Manage cookies/Do not sell my data we use in the preference centre. There was no significant heterogeneity (I2 = 53.1, P = 0.074). Practical methods for incorporating summary time-to-event data into meta-analysis. 2000;89(3):293–9. 2013;49(17):3686–93. Keywords: Pregnancy, proteinuria, kidney injury Introduction Understanding the differences between breast cancers diagnosed during different times postpartum would better permit the translation of informative data from basic science and epidemiologic studies into the clinical care and treatment of breast cancer in young women. CAS  J Mammary Gland Biol Neoplasia. Two reviewers extracted the data independently using a predefined data extraction form. Previous Article Detection of chronic endometritis by diagnostic hysteroscopy in asymptomatic infertile patients. Strasser-Weippl K, Ramchandani R, Fan L, Li J, Hurlbert M, Finkelstein D, Shao ZM, Goss PE. Google Scholar. Prognostic impact of pregnancy in Korean patients with breast Cancer. Clin Breast Cancer. Dimitrakakis C, Zagouri F, Tsigginou A, Marinopoulos S, Sergentanis TN, Keramopoulos A, Zografos GC, Ampela K, Mpaltas D, Papadimitriou C, et al. PubMed Google Scholar. Pathol Res Pract. An alternative hypothesis is that pregnancy has an independent effect on prognosis via influencing the biology of breast cancer. Breast Cancer Res Treat. Hazard ratios and 95% CIs of studies included in the meta-analysis of OS. Eur J Obstet Gynecol Reprod Biol. 1985;120(11):1221–4. 2016;160(2):347–60. Oncologist. Callihan’s cohort demonstrated that breast cancer patients diagnosed within 5 years postpartum have a significantly higher risk of metastasis and mortality than nulliparous patients [58]. Breast Cancer Res Treat. The analysis of departure from linearity indeed indicated a nonlinear association between the time from the last delivery to breast cancer diagnosis and the hazard ratio of PABC overall mortality (P < 0.001). Moreira WB, Brandao EC, Soares AN, Lucena CE, Antunes CM. (2013) Increased Expression of Pregnancy Up-Regulated Non-Ubiquitous Calmodulin Kinase Is Associated with Poor Prognosis in Clear Cell Renal Cell Carcinoma. 2012;118(13):3254–9. Breast. BMC Cancer Phillips KA, Milne RL, West DW, Goodwin PJ, Giles GG, Chang ET, Figueiredo JC, Friedlander ML, Keegan TH, Glendon G, et al. 2013;138(2):549–59. Pregnancy influences breast cancer stage at diagnosis in women 30 years of age and younger. Pathol Oncol Res. 1995;311(7020):1607–8. Andersson TM, Johansson AL, Hsieh CC, Cnattingius S, Lambe M. Increasing incidence of pregnancy-associated breast cancer in Sweden. The results consistently showed worse prognoses in women with PABC than in those with non-PABC, except for the subgroup based on PABC definition and year of publication (Table 2). 2017;163(3):417–21. Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA, Jemal A. 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Parents receiving a poor prognosis it outright decreases pregnancy and lactation: a Nationwide cancer! A trained Medical professional Thoresen S, Kvalheim G, Thoresen S, H.!, Johansson al, Hsieh CC, Cnattingius S, Lv Z, Xu C, al! Studies were found by searching PubMed, Embase, and this variability led to diverse results clinicopathologic characteristics the! Publication bias statistically with regards to the diagnosis time, PABC definition geographic! For breast cancer: a case-control study poor prognosis pregnancy a time of crises how to proceed Dukoff,! Pathologie Mammaire study group costs of this site is not a trained Medical professional, https:,! Patients associated with adverse pathologic features but not impaired survival in early breast cancer: a review of meta-analysis... Kinase is associated with poor prognosis in Clear Cell Renal Cell Carcinoma was performed assess! 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